Cutaneous Constitutive Nitric Oxide Synthase Activation in Postural Tachycardia 1 Syndrome with Splanchnic
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چکیده
Cutaneous Constitutive Nitric Oxide Synthase Activation in Postural Tachycardia 1 Syndrome with Splanchnic Hyperemia 2 3 Julian M. Stewart*, Abhinav Nafday, Anthony J. Ocon, Courtney Terilli*, Marvin S. 4 Medow*. 5 6 Department of Pediatrics* and Physiology†, New York Medical College, Valhalla, NY 7 New York Medical College, Valhalla, New York 8 9 Stewart Short Title: Constitutive NOS in POTS 10 11
منابع مشابه
Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia.
Models of microgravity are linked to excessive constitutive nitric oxide (NO) synthase (NOS), splanchnic vasodilation, and orthostatic intolerance. Normal-flow postural tachycardia syndrome (POTS) is a form of chronic orthostatic intolerance associated with splanchnic hyperemia. To test the hypothesis that there is excessive constitutive NOS in POTS, we determined whether cutaneous microvascula...
متن کاملDecreased microvascular nitric oxide-dependent vasodilation in postural tachycardia syndrome.
BACKGROUND One variant of postural tachycardia syndrome (POTS), designated low-flow POTS, is associated with decreased peripheral blood flow related to impaired local vascular regulation. METHODS AND RESULTS To investigate the hypothesis that microvascular endothelial dysfunction produces decreased peripheral blood flow in low-flow POTS, we performed experiments using laser-Doppler flowmetry ...
متن کاملCutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.
Low flow postural tachycardia syndrome (POTS), is associated with reduced nitric oxide (NO) activity assumed to be of endothelial origin. We tested the hypothesis that cutaneous microvascular neuronal NO (nNO) is impaired, rather than endothelial NO (eNO), in POTS. We performed three sets of experiments on subjects aged 22.5 +/- 2 yr. We used laser-Doppler flowmetry response to sequentially inc...
متن کاملAngiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome.
Low-flow postural tachycardia syndrome (POTS) is associated with increased plasma angiotensin II (ANG II) and reduced neuronal nitric oxide (NO), which decreases NO-dependent vasodilation. We tested whether the ANG II type 1 receptor (AT(1)R) antagonist losartan would improve NO-dependent vasodilation in POTS patients. Furthermore, if the action of ANG II is dependent on NO, then the NO synthas...
متن کاملDefects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Postural tachycardia syndrome (POTS) is associated with increased plasma angiotensin II (Ang II). Ang II administered in the presence of NO synthase inhibition with nitro-L-arginine (NLA) and Ang II type 1 receptor blockade with losartan produces vasodilation during local heating in controls. We tested whether this angiotensin-mediated vasodilation occurs in POTS and whether it is related to an...
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تاریخ انتشار 2011